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Adaptive evolution of the vertebrate skeletal muscle sodium channel Genet. Mol. Biol.
Lu,Jian; Zheng,Jianzhou; Xu,Qinggang; Chen,Keping; Zhang,Chiyu.
Tetrodotoxin (TTX) is a highly potent neurotoxin that blocks the action potential by selectively binding to voltage-gated sodium channels (Na v). The skeletal muscle Na v (Na v1.4) channels in most pufferfish species and certain North American garter snakes are resistant to TTX, whereas in most mammals they are TTX-sensitive. It still remains unclear as to whether the difference in this sensitivity among the various vertebrate species can be associated with adaptive evolution. In this study, we investigated the adaptive evolution of the vertebrate Na v1.4 channels. By means of the CODEML program of the PAML 4.3 package, the lineages of both garter snakes and pufferfishes were denoted to be under positive selection. The positively selected sites identified...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Skeletal muscle voltage-gated Na (Na v1.4) channel; Tetrodotoxin (TTX); Positive selection; Pufferfish; Garter snake.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200026
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Poisoning after ingestion of pufferfish in Brazil: report of 11 cases J. Venom. Anim. Toxins incl. Trop. Dis.
Simões,Eneida Márcia de Souza; Mendes,Thelma Marly Abreu; Adão,Angelino; Haddad Junior,and Vidal.
In this brief communication the authors report eleven cases of human poisoning caused by ingestion of pufferfish meat. Three patients (two children and one adult) were seriously affected. The circumstances that precipitated the poisoning are discussed as well as the clinical aspects observed. No deaths were registered and the patients did not present sequelae after the episode.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Pufferfish; Marine poisonings; Poisonous animals; Poisonous fish; Tetrodotoxin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200105
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Supernumerary chromosomes in the pufferfish Sphoeroides spengleri: first occurrence in marine Teleostean Tetraodontiformes fish Genet. Mol. Biol.
Alves,Anderson Luis; Porto-Foresti,Fábio; Oliveira,Claudio; Foresti,Fausto.
Cytogenetic analyses carried out in eight specimens of Sphoeroides spengleri revealed the presence of 2n = 46 chromosomes (20 M/SM and 26 ST/A). Besides the standard karyotypical set, the presence of B microchromosomes was observed in two individuals, ranging from 0 to 2 microchromosomes per cell. A karyotype composed by 2n = 46 chromosomes with occurrence of M and SM chromosomes is considered basal for the species from the clade comprising the families Tetraodontidae, Balistidae, and Diodontidae, although it represents a derived condition for the order Tetraodontiformes, whose basal karyotype would be composed by 2n = 48 acrocentric chromosomes. The occurrence of B microchromosomes in marine Tetraodontiformes fish was not known, and this represents the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: B chromosome; Pufferfish; Sphoeroides spengleri.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000200014
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